The phrase "a mark was established" is correct and usable in written English.
It can be used when referring to the creation or setting of a standard, benchmark, or significant point in a process or event.
Example: "After years of research, a mark was established for the minimum safety standards in the industry."
Alternatives: "a standard was set" or "a benchmark was created."
The Co-operative launched the UK's first own-label Fairtrade wine in 2000 before the mark was established.
The previous shortest mark was established as long ago as 1972 when Jack Nicklaus arrived at Muirfield for the Open championship holding three of the four majors.
To date there is no functional data on how the repressive mark is established but PfKMT1, a member of the SET domain containing family, is a potential lysine methyl transferases candidate (Cui et al., 2008).
We assess a growing body of literature, including treatment of how the mark is established, the patterns of methylation, and the functional consequences of this epigenetic signature.
The H3K27Ac mark is established by CBP/p300 acetyltransferase [ 13, 14] and is likely erased by RBP3/HDAC1 [ 15].
The H3K27me3 mark is established by the methyltransferase EZH2 within the Polycomb Repressor Complex 2 (Pengellyetgelly et al., 2013), which effectively provides a counterbalance to factors that promote H3K4me3 and active expression (Bernstein et al., 2006).
This chromatin mark is established on unmethylated CpG island genes early in development and then maintained in differentiated cell types by the presence of an EZH2-containing P complex.
The above changes in Blcap expression levels in Dnmt3l−/+ embryos are consistent with the notion that this methylation mark is established during oogenesis and that in the offspring, it acts as the ICR of the Blcap locus.
In the event of X chromosome inactivation, robust epigenetic marks are established in a long noncoding Xist RNA-dependent manner, giving rise to a distinct epigenetic landscape on the inactive X chromosome (Xi).
Elucidating how DNA methylation marks are established in the germline has been a challenge for nearly 20 years, but represents a key step towards a full understanding of several biological processes including genomic imprinting, epigenetic reprogramming and the establishment of the pluripotent state in early embryos.
