The walls of the primitive brain divide into an inner ependymal, an intermediate mantel, and outer marginal layer by E10, whereby the ependymal layer that ultimately forms the lining of the ventricles of the brain is the thickest layer.
TBR2 was strongly expressed by some cells in the marginal layer and weakly expressed by a few cells in the cortical plate (Fig. 2).
GAP43-positive axons were plentiful in the marginal layer and in the intermediate zone, confirming a previous observation by Milosevic et al. (1995) with some immunoreactivity seen in the VZ.
The proliferating cells of the ventricular zone shed postmitotic cells into the marginal layer from embryonic day (E) 9.5 to E13 of mouse development.
Regarding the cochlea, the superficial marginal layer of the stria vascularis was always CMV-positive (15 inners ears).
In zebrafish, Dia controls cell movements and convergent extension during gastrulation possibly as an effector of the wnt signaling pathway., In embryos depleted of Dia2, cells of the deep marginal layer, prechordal plate, and lateral epidermis lose protrusions and blebs.
13 17 Hch alone can induce profound oedema in the strial marginal layer, and slight oedema in the outer hair cells, primarily in the basal turn of the cochlea, which will cause chronic auditory dysfunction if dietary cholesterol levels remain high for a long time.
This should be considered a critical period in cortical development because, as this study confirms, the first synapses form (Kostović and Rakic 1990) and thus spontaneous network activity in the marginal layer and subplate could influence development of the cortical plate.
In this case, the oil flow is considered within a continuum (the volume of a capillary or a pore), and the restructuring processes taking place where the oil contacts with the wall of the channel, leading to the formation of marginal layers are ignored.
Histologic analysis of P21 mice revealed a thicker cerebral cortex from rostral to caudal telencephalon, a blurring of the gray white junction, a smaller marginal zone (Layer I) and apparent lamination defects (Fig. 2A and B) in the mutant.
