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A marginal dose of 13 Gy or greater was found to be a significant predictor of improved PFS.
Next, we performed an allotransplantation of a marginal dose of WT islets in recipient Erα−/− mice followed by treatment with vehicle or PPT.
A marginal dose of 1,000 islet equivalents (IEQ) of human islets were transplanted under the kidney capsule of recipient mice.
To explore this hypothesis, we used an insulin-deficient model with xenotransplantation of a marginal dose of human islets in nude mice rendered diabetic with streptozotocin.
Here, we used an insulin-deficient mouse model with xenotransplantation of a marginal dose of human islets to test the hypothesis that oestrogens improve islet engraftment during PIT.
In these mice, we performed either sham transplantation or xenotransplantation of a marginal dose of human islets (1,000 IEQ) under the renal capsule (PIT).
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Analyses revealed a marginal dose-related effect of biperiden in the minipigs (Doses X Sessions interaction: F5,35 = 2.21, p = 0.0748, Doses: F3,35 = 3.64, p = 0.0093; Sessions: F1,7 = 4.21, p = 0.0792), with higher doses (except 15 mg.kg-1) appearing to decrease RM performance (see Table 1).
Thus, we recommend a high marginal dose (≥20 Gy), when possible, being given even for recurrent BM after WBRT, by referring to the results of multivariate analysis for local tumor control (Table 5).
Thus, we performed this retrospective study to evaluate the tumor control, hearing outcomes, and possible prognostic factors of hearing loss in VS patients treated with CK, by using a fixed marginal dose of 1800 cGy in 3 sessions.
The marginal Dose X Sessions interaction suggests that the impairment induced by biperiden was dose dependent.
Another reason was that the marginal dose deviation caused by setup deviation might be relatively larger.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com