A favorite psalm or manageable activity such as fishing that brings them a sense of sacredness can help.
As corporations have broken down work into manageable activities and then consolidated capabilities into areas of expertise, employee-related activities have typically fallen into HR's domain.
Promising phase II activity and a manageable safety profile with ixabepilone have been seen in a wide range of tumor types, including heavily pretreated/resistant and early-stage breast cancer.
PEP02 demonstrates moderate antitumour activity with a manageable side effect profile for metastatic, gemcitabine-refractory pancreatic cancer patients.
In conclusion, temsirolimus appears to have only modest activity with a manageable toxicity profile in advanced NEC.
nab-Paclitaxel 300 mg/m q3w demonstrated substantial antitumor activity with a manageable safety profile in this patient population.
In phase 1 and 2 clinical trials, lenvatinib demonstrated antitumor activity and a manageable toxicity profile as a single agent [ 16- 18].
It has clinical activity with a manageable safety profile in phase 1 and 2 clinical trials, in patients with BRAF V600 -mutated metastatic melanoma [ 13].
Another anti-PD-1 monoclonal antibody, lambrolizumab (Merck Sharp & Dohme Corp ,Whitehouse Station, NJ, USA), has shown antitumor activity with a manageable side effect profile in a Phase I trial of patients with advanced melanoma.
Sequential neoadjuvant treatment with dose-dense nab-paclitaxel followed by a cytotoxic and targeted agent combination had significant activity and a manageable safety profile in patients with HER2-positive early BC [ 43].
The concept of local economy, as Elsen proposes it [6, p. 6] is primarily concerned with the dynamics of local economic structures and economic activities within a manageable territory.
