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The phrase "a major weakness of" is correct and usable in written English.
It can be used when discussing a significant flaw or disadvantage related to a particular subject, concept, or entity.
Example: "A major weakness of the current strategy is its lack of adaptability to changing market conditions."
Alternatives: "a significant flaw in" or "a critical drawback of".
Exact(60)
Herein lies a major weakness of the powerful: they easily assume that the weak will give up in the face of overwhelming force.
Crack formation and progression under tensile stress is a major weakness of concrete.
Mr. Gore's style had seemed a major weakness of his candidacy.
A major weakness of the Manchester plan could turn out to be the complicated governance arrangements.
A major weakness of Bradford's work is his reliance on stereotypes of his black subjects.
Analysts say a major weakness of the deal, besides the murky Kremlin connection, is that Magna has never made cars.
I view this as a major weakness of the critics because such policies are what society should be talking about.
From the point of view of shipowning interests, however, a major weakness of limitation law has been the fact that limitation proceedings were not given international recognition.
The exclusion of high-polluting industries such as international aviation and shipping was seen as a major weakness of the historic agreement reached last December.
Lurie feels poor talent evaluation has been a major weakness of the organization, and he said so in an interview with Philadelphia Magazine in August.
However, a major weakness of the RM model is that it generates data according to an equal-variance binormal model for each reader.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com