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The phrase "a major void in" is correct and usable in written English.
It can be used to describe a significant lack or absence of something in a particular context or area.
Example: "There is a major void in the research regarding the long-term effects of the medication."
Alternatives: "a significant gap in" or "a substantial absence of".
Exact(13)
The loss of Beltran will leave a major void in the Mets' lineup.
The joy that emanated from your presence has left a major void in our lives, nothing is the same.
"This is going to leave a major void in my desire for local news and neighborhood happenings," another wrote.
Steve Bannon, White House chief strategist, was removed from his position, leaving a major void in the administration.
Attention has now shifted to "Good Morning America," where Ms. Sawyer will leave a major void in the morning.
This book, a collaboration between two scholars and an activist, fills a major void in LGBT, Latino/a, and activist histories, privileging the first-person recollections of Latino and Latina leaders in LGBT movements in the United States.
Similar(47)
Hydrologic assessments of individual plots and fields with tile drainage are becoming common; however, a major void exists in our understanding of the contribution of systematic tile drainage to watershed hydrology.
"A major void," said Maggie Cassidy, who works in online advertising.
The local council said "a major void" had been found under the A4058 in Hopkinstown near Pontypridd by Welsh Water workers.
Rhondda Cynon Taf council said "a major void" measuring six cubic metres was found under the A4058 in Hopkinstown near Pontypridd.
A major void facing many DIY investors is what happens when they're no longer in the driver's seat.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com