The phrase "a major variation of" is correct and usable in written English.
It can be used when discussing significant differences or changes in a particular subject, concept, or item compared to its original form.
Example: "The new model represents a major variation of the previous design, incorporating advanced technology and user-friendly features."
Alternatives: "a significant alteration of" or "a substantial modification of".
Such a major variation in the geochemistry of a watershed within an urbanized environment can be easily attributed to anthropogenic interferences.
When a naso-buccal sensor is used, major variations of Pa-E′CO2 along time and poor limits of agreements between EtCO2 and PaCO2 preclude the use of EtCO2 measurement to predict PaCO2 or its variation over time during NIV delivered for acute hypercapnic respiratory failure.
But that does not merit an instant dismissal of a finding of major variation in even supposedly 'incognito' Google search results.
The level of uncertainty surrounding the risk of introduction was rather constant for both areas, with one exception: the level of uncertainty was far higher than average in Provence in October 2012 as a result of major variation in local temperatures.
In addition to being a major source of variation, mutation may also function as a mechanism of evolution when there are different probabilities at the molecular level for different mutations to occur, a process known as mutation bias.
Our results show little evidence for genetic diversity among the natural plants sampled in the Yukon, thereby ruling out genetic variation as a major source of transcriptional variation in these plants.
A major contribution to variation of sLL CD4+ cell counts was tube to tube variation of the calibration beads, amounting to an uncertainty of 3.6%.
For example, a major source of variation is whether the disability is visible or invisible (Davis, 2005; Banks and Kaschak, 2003).
Analysis of expression levels revealed clear association of the functional and nonfunctional alleles with early and late flowering, suggesting that Hd1 is a major determinant of variation in flowering time of cultivated rice (Takahashi et al. 2009).
These indicate that cancer onset is a major source of variation in the expression of the validated biomarker.
