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The phrase "a major use of" is correct and usable in written English.
It can be used when discussing the primary or significant application of something in a particular context.
Example: "One major use of renewable energy is to reduce greenhouse gas emissions."
Alternatives: "a primary application of" or "a significant utilization of".
Exact(30)
But each burger is a result of a major use of natural resources.
A major use of results from subgroup analysis is to generate hypothesis for future clinical trials.
Most nitrates are soluble in water, and a major use of nitric acid is to produce soluble metal nitrates.
A major use of profile data on ultrathin sections is in assessing gold particle labeling of cell components.
Citing the highly fragmented market for packaging material, a major use of aluminum, Mr. Ortslan said, "To work on your own is costly".
For these reasons, a major use of tabular alumina is in the production of high-quality refractories, the materials used for lining industrial furnaces.
Similar(30)
A major uses of health measurement scales is to detect health status changes over time, and a priority may be efficiency, i.e., responses achieved using the shortest possible questionnaire [ 11, 12].
A highly visible and major use of NHANES nutritional data is to support the development and evaluation of public health policies and programs.
Computer simulation is increasingly being used to aid circuit design and optimization and is likely to be a major future use of the computer in mineral processing.
A major industrial use of ethanol is to convert it by oxidation into acetaldehyde (CH3CHO).
Company co-founder and CEO Emil Eifrem explained there are a couple of major use cases for neo4j.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com