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The phrase "a major underlying role" is correct and usable in written English.
It can be used to describe an important and foundational function or influence that something has in a particular context.
Example: "The research indicates that diet plays a major underlying role in overall health and well-being."
Alternatives: "a significant foundational role" or "a crucial underlying function."
Similar(60)
It also spends $100 million a year overseas to fight AIDS, a major underlying factor.
The Wnt signaling pathway plays a key role in organ and tissue homeostasis, and when dysregulated, can become a major underlying mechanism of disease, particularly cancer.
A major underlying rationale for imposing a substantial fine in a case like this is it's deterrent value".
A major underlying rationale for imposing a substantial fine in a case like this is its deterrent value".
A major underlying factor is the inconvenience of special collection programs compared to general disposal.
NCDs are a major underlying reason why pregnant women die.
A major underlying problem is the limited control that the UN has over individual peacekeepers.
A major underlying factor is resistance to different chemotherapeutics.
Malnutrition remains a major underlying cause of deaths, with 36 per cent of children stunted.
Childhood malnutrition is a serious challenge in Sub-Saharan Africa (SSA) and a major underlying cause of death.
Several studies have indicated that insulin resistance is a major underlying cause of MetS [ 4- 6].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com