The phrase "a major underlying cause" is correct and usable in written English.
It can be used when discussing significant factors that contribute to a particular issue or situation.
Example: "The researchers identified a major underlying cause of the decline in bee populations, which is linked to pesticide use."
Alternatives: "a significant root cause" or "a primary contributing factor."
A major underlying cause of restenosis, as well as of stenosis following coronary bypass and other vascular grafting, is the abnormal accumulation of neointimal vascular smooth muscle cells (VSMCs) resulting from media-to-intima migration and proliferation.
A major underlying cause of these features seems to be the increase in population size of neural progenitors in the outer subventricular zone (OSVZ), a specialized germinal zone characteristic of the developing cerebral cortex in higher mammals.
Rather, they should start exercising and lose the excess weight that is a major underlying cause of elevated CRP levels in the first place.
The current study, therefore, reveals that desolvation can be a major underlying cause for the apparently counterintuitive structure-activity relationship (SAR) outcomes, and indicates that understanding this factor can improve our ability to predict binding affinity and to design more potent ligands.
We further found that a major underlying cause for this outcome is that the introgression process weakened the capacity in Na+ exclusion under the salt stress condition, and hence, escalated the injuries of Na+ and Cl- in shoots of RZ35.
ADPKD is associated with significant morbidity, and is a major underlying cause of end-stage renal failure (ESRF).
Accordingly, we investigated the association between serum cathepsin S and the two major underlying causes of diabetes impaired insulin sensitivity and impaired insulin secretion in a community-based sample of elderly men without diabetes.
In terms of spatial accessibility, most stations are well accessed, while five major underlying causes were the impedances resulting in poor accessibility.
A fatal case of p(H1N1) infection was defined as confirmed p(H1N1) infection in a severe case who died or whose death certificate listed p(H1N1) influenza as a major or underlying cause of death.
For example, in a Connecticut study of 272 randomly selected autopsies and their corresponding death certificates, Dr. William H. Hartmann, executive vice president of the American Board of Pathologist, said, "In 29percentt of the deaths, a major disagreement on the underlying cause of death led to a reclassification of the death in a different major disease category".
