The phrase "a major technical problem" is correct and usable in written English.
You can use it when discussing significant issues related to technology or technical processes.
Example: "The team is currently addressing a major technical problem that is affecting the software's performance."
Alternatives: "a significant technical issue" or "a critical technical challenge."
The Longitude Prize was set up 300 years ago to find the solution to what was then a major technical problem: how to navigate the seas safely.
NASA is still aiming for a space shuttle launching in May, but there is so little extra time left in the schedule that the plan could be derailed if a major technical problem arose, agency managers said.
WASHINGTON, Feb. 28 — NASA is still aiming for a space shuttle launching in May, but there is so little extra time left in the schedule that the plan could be derailed if a major technical problem arose that needed fixing, NASA managers said Tuesday.
A major technical problem may arise if silica that is released during the olivine reaction would form a layer on the olivine grains, preventing the reaction to proceed.
That's obviously not a major technical problem anymore, but my feeling is Google is holding back from adding something like this to Now for the time being to avoid making users feel queasy about the privacy implications of the service.
Consequently, large numbers of sections from different animals have to be processed, raising a major technical problem, namely the loss of three-dimensional (3D) spatial consistency across brains.
The other major technical problem was the difficulty the voice response technology had recognizing participants' voices.
Panel members, speaking at a news conference in Houston after their second public meeting, said NASA still had major technical problems to overcome before a return to flight, planned for fall 2004.
Now that a recount is under way, Michigan officials are indeed finding major technical problems.
"Now, there's one paragraph saying that you're not allowed to engage in 'irresponsible circulation of gatherings of personal information.' One thing that's always been written in the terms is that you're not allowed to run things that don't work from a technical point of view, or something that can cause us major technical problems.
When asked, four (6.1 %) participants reported major technical problems experienced during the calls: one had a temporary disturbance with her telephone line due to reconfiguration of the intercom system in her building while three experienced voice recognition problems that led to call disconnection.
