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A major technical handicap in the development of hybrid rice using WA-CMS is a limited source of maintainer lines, as many indica elite cultivars are known to carry restorer genes for WA-CMS lines and cannot be used as maintainer lines (Virmani 1994).
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If you have none, it's a major handicap to overcome.
And if prime location is everything, his venture had a major handicap.
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In years past, such damage has proved a major handicap in November.
The world shortage of fertilizer is a major handicap to all developing countries in the medium term.
As this generation of entrepreneurs tries to deploy the Internet, a major handicap is the absence of management expertise.
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