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"a major struggle" is correct and usable in written English.
You can use it at any time to describe a challenging or difficult situation. For example: "She faced a major struggle after the death of her spouse."
Exact(36)
We still have a major struggle ahead.
Today, finding support for AIDS research remains a major struggle.
Beauty usually won, but only after a major struggle.
"In every other recession it was a major struggle to extend unemployment benefits.
Leaving my flat became – if not a major struggle, then certainly effortful.
To the extent that they are involved in a major struggle against Iran, they do so in explicit coordination with the United States.
Similar(24)
Shari happened to be in a major power struggle with Moonves over the company's future: She wanted to re-merge Viacom, which is struggling, with CBS, which is doing well.
In reality it was a major power struggle between Thatcher and Heseltine at her moment of greatest political danger until she was eventually brought down in 1990.
California is in the midst of a major regulatory struggle that shows both the perils and potential promise of trying to bring clarity to the fast-growing industry.
In the Hyderabad state, especially in the Telangana region, the Communist Party organized a major armed struggle from 1946 to 1951 on behalf of the peasants and workers against the landlords and the princely ruler Nizam.
The sides meet again in Ukraine next Thursday with Glentoran facing a major uphill struggle.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com