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The phrase "a major source of risk" is correct and usable in written English.
You can use it when discussing factors that contribute to potential danger or uncertainty in various contexts, such as finance, health, or project management.
Example: "Investing in volatile markets can be a major source of risk for investors looking for stable returns."
Alternatives: "a significant risk factor" or "a primary risk source."
Exact(8)
Disasters represent a major source of risk for the poor.
Derivatives contracts are a major source of risk, and Mr. Soros would limit their use.
Requirement change is a major source of risk to software development projects.
Klei, L. et al. Common genetic variants, acting additively, are a major source of risk for autism.
For many sectors, supply chains are becoming both a major source of risk and also an opportunity for positive change.
The reality is that changes in infrastructure usually lag changes in products and services, and that imbalance can be a major source of risk.
Similar(52)
Although this study did not measure the overall effect of the decreased number of veterinarians who treat equids in Queensland, participants viewed the decrease as a major source of increased occupational risk for the remaining equine practitioners.
Extreme heat events are a major source of climate-related risk for older adults (Ebi and Meehl 2007; Gosling et al. 2009; Green et al. 2001; Medina-Ramón and Schwartz 2007; Ostro et al. 2009), with older Americans experiencing disproportionate risks of heat-related mortality (Ebi and Meehl 2007; Oudin Åström et al. 2011).
But Huntington Park officials say the new bond issue represents only a small risk to keep the casino--a major source of revenue--afloat.
Moreover, autopsy studies point to vascular damage rather than Alzheimer-type pathology as a major source of the increased dementia risk in people with diabetes (23).
Surveillance or detection bias is a major source of bias when analysing the risk of developing breast cancer with different prognostic characteristics in women using HRT.
More suggestions(16)
a major source of hazard
a major source of harm
a large source of risk
a major source of hazards
a key source of risk
a troubling source of risk
a single source of risk
a meaningful source of risk
a major contribution of risk
a major element of risk
a timely source of risk
a significant source of risk
a major amount of risk
a critical source of risk
a second source of risk
a major area of risk
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com