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The phrase "a major source of difficulty" is correct and usable in written English.
It can be used when discussing challenges or obstacles in various contexts, such as academic, professional, or personal situations.
Example: "The lack of clear communication was a major source of difficulty in completing the project on time."
Alternatives: "a significant cause of trouble" or "a primary source of challenges."
Exact(5)
However, some of the features that make supervisory control an attractive paradigm to solve theoretical problems are often a major source of difficulty in implementing a controller: such is the case, for instance, of the abstraction level usually considered in SCT.
Ambiguous terminology is a major source of difficulty in this venture.
Word misspellings are a major source of difficulty in de-identifying free text.
As in our investigation, the issue of double-barreled items was a major source of difficulty found in the IKDC.
Loneliness is a human condition which is widely recognised as a major source of difficulty for older people (Cattan et al. 2005, 2009; Victor et al. 2000).
Similar(55)
In the end, the committee failed, and many Democrats pointed at Mr. Kyl as a major source of the difficulty.
However, the underlying distributions for all three question sources on the measure's relevance, fluency, and ambiguity show that all were similar and all were probably not a major source of pedagogical difficulty.
Another major source of difficulty is missing (latent) variables.
Eating and drinking difficulties are a major source of ill health and stress across the stages of dementia in multiple settings.
The focus of difficulty lies in the hypothesis that interference from established memories is a major source of proactive inhibition.
The strikes seem certain to batter the nation's tourism industry, which generated about $23 billion in revenue last year but was already experiencing difficulties because of security concerns among travelers and tensions with Russia, a major source of visitors to Turkey.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com