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The phrase "a major slice of" is correct and usable in written English.
It can be used to refer to a significant portion or share of something, often in a figurative sense.
Example: "A major slice of the budget will be allocated to marketing efforts this year."
Alternatives: "a significant portion of" or "a large share of".
Exact(13)
He now fears completely losing his grip on a major slice of the UK's high street.
It also is shaping up to be a major slice of retail heaven.
With a major slice of credit no longer in demand, the borrowing figures were bound to tumble.
In developing countries like Egypt, where food accounts for a major slice of average income, such inflation is becoming a major problem.
Struggling Hovis is to get £200 million of investment under a deal that will hand a major slice of the operation to an American firm.
The sale of office buildings in San Francisco and Silicon Valley represents a major slice of the remainder of the Equity Office Properties portfolio Blackstone acquired for $39 billion in 2007.
Similar(47)
His one major slice of luck here was a walk-over against Safin in the third round, the Russian having injured his left arm.
A successful deal for HMV's 125 stores would see Ashley grab another major slice of the high street following Sports Direct's acquisition of the bike specialist Evans Cycles in October and department store chain House of Fraser in August, both of which were bought out of administration.
Buttler's innings contained one major slice of luck.
A major advantage of the slice model is that it can be used not only for animal but also for (fibrotic) human kidney tissue.
As someone who shops a lot online, Project Slice solves a major pain point of keeping track of all purchases, from Amazon to PeaPod, even for daily deal sites.
More suggestions(18)
a considerable slice of
a substantial slice of
a major share of
a major cut of
a major piece of
a major chunk of
a major bit of
a great slice of
a major stretch of
a broad slice of
a major tranche of
a serious slice of
a major fraction of
a major segment of
a major ring of
a true slice of
a major driver of
a major component of
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com