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The phrase "a major shift of" is correct and usable in written English.
It can be used to describe a significant change or transition in a particular context, such as in business, technology, or social dynamics.
Example: "The company experienced a major shift of its marketing strategy to adapt to changing consumer preferences."
Alternatives: "a significant change in" or "a substantial transition of".
Exact(36)
The results represent a major shift of vision for these two vastly important American photographers.
For the state to seek to regulate them was a major shift of emphasis.
Our economic reform plan will entail a major shift of capital from the value-destroying state sector to private firms.
A major shift of NHS funding away from hospitals into out of hospital services, including GP surgeries.
I think it can, but it will involve a major shift of thinking in the arts sector itself.
"If other states follow us, it would represent a major shift of political power back to these poor urban communities".
Similar(23)
These combined departures and their subsequent replacements also signaled the beginning of a major shift in focus of the M A S H series as a whole with story and script focus emphasizing the character of Hawkeye Pierce, played by Alan Alda.
The prolonged lag phase before the recovery of cell growth indicates a major shift in physiology of cells evolved under inhibitor stress.
Mayor Richard M. Daley's decision not to seek re-election next year raises the prospect of a major shift in the balance of power in City Hall.
According to the World Health Organization, those diseases, including cardiovascular disease, Type 2 diabetes and certain cancers, are now part of a major shift in the cause of death around the world.
These results suggest the absence of a major shift in the migration of T cells into the peritoneal cavity following TNFα treatment.
More suggestions(15)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com