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The phrase "a major shift from" is correct and usable in written English.
It can be used to describe a significant change or transition from one state, condition, or situation to another.
Example: "The new policy represents a major shift from the previous approach to environmental regulations."
Alternatives: "a significant change from" or "a substantial departure from".
Exact(60)
The most recent poll by the Pew Research Center found most Americans think pot should be legal, a major shift from just a decade ago when voters opposed legalization by a 2-to-1 margin.
This is a major shift from the "cap and trade" scheme it previously introduced.
That change signals a major shift from Labour's centralising, spin-laden way of being.
His announcement was seen as a major shift from the policy pursued under Tony Blair.
The picture in Sri Lanka is emblematic of a major shift from 20 years ago, when India was the only power center in the region.
The move is a major shift from EDS's core work, and raises serious questions about involvement of the private sec tor in delivery and management of public services".
That's not such a major shift from the dynamic seen in previous movies, though Luthor in the comics has at times been a far more physically powerful villain.
On the surface, it will be a major shift from the complex, read-oriented 3-4 defense instituted by the former coordinator Rob Ryan, who was fired.
Gen. Jefforey A. Smith, the commander of the Cadet Command, said the move was not part of a major shift from rural settings to urban ones.
The Obama administration — in a major shift from President George W. Bush's isolation policy toward Iran, which he once branded part of an "axis of evil" — has expressed an openness to direct diplomatic contacts with Iran.
This represents a major shift from past years, when I wholeheartedly applauded the holiday's sharp-fanged vampires, headless horsemen and even trick-or-treaters dressed as bloodied dead surgeons with an eyeball dangling from its socket.
More suggestions(15)
a fundamental shift from
a large shift from
a severe shift from
a great shift from
a substantial shift from
a large scale shift from
a major toothpaste from
a major business from
a major commission from
a major discount from
a major outbreak from
a major performance from
a major polluter from
a major risk from
a major figure from
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com