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The phrase "a major setback to" is correct and usable in written English.
It can be used when discussing an event or situation that has caused significant difficulty or delay in progress towards a goal.
Example: "The unexpected storm was a major setback to the construction schedule, pushing the completion date back by several weeks."
Alternatives: "a significant obstacle to" or "a considerable hindrance to".
Exact(59)
"It was a major setback, to this city and its psyche".
Stanley said he considered it a major setback to his efforts in Uganda.
Its failure would be a major setback to progressivism and integration in the Middle East.
The loss of the seat was "a major setback to U.S. diplomacy," the report said.
The cancellation is a major setback to the world title ambitions of both fighters.
If taken, it could be a major setback to the Shabab by cutting off their supply line.
However, a loss for Olson and Boies could be a major setback to the movement for marriage equality.
Ed Cox, the director of the IPPR North thinktank, described the announcement as a "major setback to the Northern powerhouse".
A rejection tonight would be a major setback to the mayor and the chancellor, at a most difficult time.
Colon's injury could be a major setback to the Steelers' plans to put a greater emphasis on the run this season.
Haq's death was a major setback to the American anti-Taliban effort and to Pakistan's hopes of forming a broad-based new government in Afghanistan.
More suggestions(25)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com