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The phrase "a major setback during" is correct and usable in written English.
It can be used to describe a significant obstacle or difficulty encountered at a specific time or event.
Example: "The project faced a major setback during the final stages of development, causing delays in the launch."
Alternatives: "a significant obstacle during" or "a considerable hindrance during".
Exact(1)
Following a series of minor victories, the British suffered a major setback during Black Week between 10 17 December 1899, although no Australian units were involved.
Similar(57)
The boycott lasted a year and was a major setback for polio eradication.
Iraqi forces are battling Isis troops entrenched throughout Anbar, after liberating the province's capital Ramadi during the winter in a major setback for the militant group.
A major setback for the community involving Overhead Door occurred during the 1980s, although it began in the 1960s.
Irish police describe the seizure of guns and bomb-making material during searches in Dublin on 15 November as a "major setback" for dissident republicans.
"This was a major setback.
Or a major setback for feminism?
The fall brought a major setback.
Egypt's march toward democracy has suffered a major setback.
Last week, the good news had a major setback.
The loss of Shockey, though, is clearly a major setback.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com