The phrase "a major setback and" is correct and usable in written English.
It can be used when discussing an obstacle or difficulty that has occurred, often in the context of a larger narrative or situation.
Example: "The project faced a major setback and required additional funding to continue."
Alternatives: "a significant obstacle and" or "a considerable hindrance and".
Surgeons said that the infection was not a major setback, and that the expanders would be reinserted.
The Finnish prime minister, Matti Vanhanen, said the region's vaunted openness had suffered "a major setback and shock".
Trump's election dealt global climate progress a major setback, and that will be all the more true if he wins reelection in 2020.
Floodwater breached the defenses of the domestic airport, Don Muang, earlier this week in a major setback, and the airport director, Kanpat Mangkalasiri, said Friday that 90 percent of the airport was now flooded.
Representing 13% of the EU's population and 17% of its GDP, the exit of Britain, the EU's second largest economy, would be a major setback and would undermine the foundation of our 500 million-plus-strong internal market.
Today, while Barber insisted that the fracture was not a major setback and that he would resume practicing in a few weeks, he became the second vital offensive weapon currently sidelined.
For CM, in particular, the lack of competitiveness of laboratory moths when compared to their wild counterparts in springtime has been a major setback (Thistlewood and Judd 2003; Judd et al. 2004, 2006a, b).
The powerful aftershock measuring 7.3 in magnitude, which occurred on 12 May 2015, was a major setback, invoking safety and security concerns and also forcing one service provider to close its doors due to extensive structural damage.
It would be a major setback for China, and the global economy, if the long and proven track record of spectacular Chinese growth were to be undermined by waiting too long to make progress on financial liberalization and reform.
Without inducing a change in Pakistan's posture, the United States will have to choose between fighting a longer and bloodier war in Afghanistan than is necessary, at the cost of many young American lives and many billions of dollars, or accepting a major setback in Afghanistan and in the surrounding region.
Its failure would be a major setback to progressivism and integration in the Middle East.
