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More than a decade ago, a Federal Highway Administration study predicted that by 2005, 20percentt of American drivers would be over 65, creating a major safety problem.
Pedestrians slipping and falling is a major safety problem around the world, not least in countries with long winters such as Sweden.
David Lochbaum, a nuclear engineer at the Union of Concerned Scientists, a group that often criticizes nuclear operators, said the two tubes so far had not presented a major safety problem because they leaked, leaving obvious deposits of boron, before they could break.
With the rise of automobility in the second half of the 20th century, alcohol became a major safety problem for road traffic worldwide [9].
Then you learn that the company has a major safety problem with ignition switches on the Chevrolet Cobalt that has caused 12 deaths, and you must recall 1.6 million vehicles.
As an example, at the time of the study, drowning was recognized by the National Rescue Services Agency as a major safety problem among children.
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In October, the F.D.A. identified the first major safety problem caused by the nine antiviral drugs.
Indeed, it is reassuring that no major safety problem has been observed in more than 1,000 children treated with DHA-PQP.
Fast forward to 3pm on 6 December 2011, 30 miles away in the state capital of Charleston: the US Mining Safety and Health Administration released its investigation report concluding that the disaster was "entirely preventable", caused in part by a pattern of major safety problems and Massey's efforts to conceal hazards from government inspectors.
This has led to a lack of efficacy and to major safety problems when genes go to the wrong places.
Lack of 'communication openness' was identified as a major safety culture problem.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com