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The phrase "a major rule of" is correct and usable in written English
It can be used when discussing significant principles or guidelines that govern a particular area or subject. Example: "One major rule of effective communication is to listen actively to others."
Exact(2)
I'm about to break a major rule of journalism and do something that should color me immediately as a hack.
Together with Haldane's (1922) rule, the disproportionately large effect of the X chromosome constitutes a major rule of speciation (Coyne and Orr 1989).
Similar(56)
Therefore, all the screening instruments we plan to examine play a major rule in the determination of the frail older individual physical, functional, and biological reserves.
Another major rule of thumb, carry your personally identifiable information with you during the move -- keep it all in one box that travels with you.
Therefore, maternal inheritance of mtDNA is regarded as the major rule of mtDNA transmission in animals and humans.
Major rule of thumb: If you are in the circle, you have the right of way.
This is a bit of a tricky tip, as one of the major rules of scuba diving is to never hold your breath.
"Two major rules of American politics disappeared this year," he said.
We spoke with executives from 16 of the diploma-holders and from what they told us we have distilled seven major rules of success: Lesson one Run scared.
Even so, many students admitted they often failed to follow one of the other major rules of harm reduction: not mixing illegal substances with alcohol.
The women in my family are firm believers in social etiquette, and one of my grandmother's major rules of conduct is that you should never go barelegged.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com