The phrase "a major restriction" is correct and usable in written English.
It can be used to describe a significant limitation or constraint in various contexts, such as regulations, policies, or conditions.
Example: "The new policy imposes a major restriction on the use of company resources, limiting employees' access to certain tools."
Alternatives: "a significant limitation" or "a substantial constraint."
A major restriction, however, was the necessary assumption of mutually incoherent sources.
A major restriction of this framework was given by the assumption of non-overlapping connector interfaces.
Hitch Hiker uses a single meta manager in infrastructure mode for the creation of data aggregation overlay, which is a major restriction.
A major restriction of land application of water hyacinth compost is the possible high heavy metal concentration in the final product.
Isobutanol is known to be toxic to microbial cells (Brynildsen and Liao 2009) and this feature can be a major restriction to improve productivity.
A major restriction of the current commercial HSV systems is the frame rate, typically limited to 2000 frames per second, which appears insufficient for most female habitual phonations.
Foreigners who wish to buy property in Britain are not subject to any major restrictions, though Mr. Flanagan recommended acquiring a bank account in Northern Ireland before buying a home there.
Hence, patients of risk of suboptimal outcomes were defined as the ones in the worst quartile of the total WOMAC score at follow-up (i.e. WOMAC score >11.5) and perceiving their hip "Like an artificial joint with minimal restriction", "Like an artificial joint with major restriction" or "Like a non-functional joint".
The stability analysis is done without any major restrictions and, hence, models the full Euler equations in one dimension.
During the design of control laws for semi-active dampers, the inherent actuator limits constitute a major performance restriction.
A double-blind double-dummy design, however, would have put a lot of effort into the conduct of the trial and a major additional restriction to the study subjects.
