The phrase "a major research question" is correct and usable in written English.
It can be used when discussing significant inquiries or topics that guide research in a particular field.
Example: "The study aims to address a major research question regarding the impact of climate change on biodiversity."
Alternatives: "a key research question" or "a significant research question".
"Understanding the differences between those that do and those that don't is a major research question.
A major research question for scientists is whether that trend will persist.
A major research question in the United States is whether this rise in those who are out of the Labour Force (OLF) is structural or cyclical.
How physiological factors related to sexual differentiation may be mechanistically associated with different levels of autistic characteristics, in males and females, respectively, should be a major research question.
The etiology of delirium is unknown and given its very high frequency in aged and demented populations, it is a major research question.
Thus, a major research question of the past decade will need continuous and intensified attention: which strategies for guideline implementation are useful for specific environments and different groups of physicians [ 8, 17]?
This way, the researchers answered the major research question and concluded that implementing the selected higher order thinking (HOT) strategies had significant impact on EFL learners' level of autonomy.
We cannot rule out the possibility that patients with psychiatric disorders are included in these studies, obscuring the major research question whether inflammatory rheumatic diseases are related to a specific physiological stress responses profile.
The major research question of the study was, 'what would be the livelihoods of Prosopis-invaded households had they not been invaded by Prosopis?' To answer this question, descriptive and econometric tools were employed.
The present research aimed at one major research question concerning investigating the impacts of implementing the three higher order thinking strategies on the learner autonomy of Iran EFL learners through instructional intervention.
However, this does not necessarily address the major research question of the current study, which is to identify the minimal possible number of founders of mtDNA lineages within the approximately 2,000 year historical time frame relevant to the historical context of the Jewish Diaspora that would explain a large proportion of extant mtDNA variation in that population.
