Innate immunity, rather than anti-angiogenesis, can be a key mechanism leading to major regression by metronomic chemotherapy of some large, established tumors [ 11], as seen in work from this laboratory in implanted brain tumor models when CPA is delivered using an intermittent (every 6-day) metronomic schedule [ 12- 15].
A common defining feature to many major regression models, such as generalized linear models (GLM) or previously mentioned Cox model, is the use of a loss function to fit the parameters of otherwise analytically intractable problems.
The soil formation had sustained for ca. 5400 years and ceased at 3100 a B.P. A major pedogenic regression occurred from 3100 a B.P. because of climatic aridity and intensified dust accumulation over the Loess Plateau.
These corrections resulted in an improvement in the agreement of the measurements with the filter-based measurements, with a major axis regression relationship of y=0.83x+0.20 μg m−3 and R2 of 0.84 for nitrate and y=0.71x+0.42 μg m−3 and R2 of 0.83 for sulfate.
As one of us, Riane Eisler, predicted in her 1979 The Equal Rights Handbook, its defeat would usher in not only a massive backlash against women's rights but a major political regression.
A major histomorphological regression was seen in another 19 resected specimens.
Scores along the line-circle vector were strongly correlated to scores along ES1 in the original CPES analysis morphospace; there was no apparent structure to the residuals from a major axis regression, and there were no notable outliers (Fig. 2D).
Recent studies from this laboratory have shown that administration of CPA on a metronomic, 6-day repeating schedule activates a potent anti-tumor response in several implanted glioma models leading to major regression of large tumors that is dependent on innate [ 12- 15] as well as adaptive [ 12, 16] immune cells.
The vascular disrupting agent combretastatin A4 phosphate (CA4P) causes major regression of animal tumours when given as combination therapy.
These sub-groups were selected for illustrative purposes, based on the key predictors identified in the major regression analyses (Table 5); it should also be noted that, where appropriate, those who did not seek advice are included in these sub-groups (with zero service usage), as they also identified potential barriers.
