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The phrase "a major reason that" is correct and usable in written English.
It can be used to introduce an explanation or justification for a particular situation or decision.
Example: "A major reason that we decided to implement the new policy was to improve employee satisfaction."
Alternatives: "a primary factor that" or "a significant cause for".
Exact(59)
Your Sept. 5 editorial about the technology gender gap cited the lack of encouragement in school as a major reason that too few women enter the field.
Considering CMC station (Fig. 6a), in the northern direction of the station, there is a large open space devoid of road network which is a major reason that created the smaller service area.
A major reason that study is relevant today is Obamacare.
It is a major reason that girls drop out of school.
A major reason that it's gotten delayed is a strong desire to do modular.
And their continuity is a major reason that the region has remained so peaceful.
This inclusiveness is likely a major reason that these policies have garnered such enduring support.
It is a major reason that Dr. Scelsa developed the museum.
This so-called ice-albedo feedback is believed to be a major reason that the Arctic is warming so rapidly.
This coordinated brain response is a major reason that dieters find weight loss so hard to achieve and maintain.
Uncertainty on such points is a major reason that some of the Obamacare exchanges are in a state of disarray.
More suggestions(15)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com