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The phrase "a major realignment" is correct and usable in written English.
It can be used when discussing significant changes or adjustments in a particular context, such as business, politics, or personal circumstances.
Example: "The company announced a major realignment of its resources to better meet the demands of the market."
Alternatives: "a significant shift" or "a substantial reorganization."
Exact(44)
That means it'll be business as usual in the Senate, with Sen. Mitch McConnell (R.-Ky). remaining as majority leader, but a major realignment in the House, with Rep. Nancy Pelosi (D-Calif). expected to return to her perch as speaker, with Democrats running the committees.
"If the poll results are confirmed you are looking at a major realignment.
Is this the beginning of a major realignment, notwithstanding the index's gains yesterday?
"There needs to be a major realignment inside some of these companies for profound digital deals to happen," he said.
He said that should a major realignment happen, he hoped the Lib Dems would be "part of the nucleus".
A major realignment was also under way within the Shiite alliance that represented Mr. Maliki's biggest challenge in the south.
Similar(16)
As a result, the fringes period can be varied without a need for major realignment of the optical system and the time coincidence between the interfering beams can be easily monitored.
But others took note — particularly Richard Nixon's campaign advisor Kevin Phillips, who, in his book "The Emerging Republican Majority," saw the potential of a major partisan realignment.
It may become the latest of the world's major industries to suffer upheaval and major realignment prompted by a deregulated globalised market economy.
Yet we find sharp disagreement on whether the 1890s brought a major electoral realignment.
President Roosevelt's New Deal of the 1930s is routinely viewed as a major electoral realignment, a clear case where "history matters" and leaves an enduring legacy.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com