The phrase "a major rationale of" is correct and usable in written English.
It can be used when discussing the primary reasoning or justification behind a particular idea, action, or policy.
Example: "A major rationale of implementing this new policy is to improve employee productivity and satisfaction."
Alternatives: "a key reason for" or "a primary justification for".
The limitations of clopidogrel have served as a major rationale for the development of new P2Y(12) blockers that have superior pharmacodynamic profiles uninfluenced by concomitant therapies or specific genotypes.
A major rationale for the use of UKA is its potential as a less invasive temporizing procedure that allows revision to TKA when failure eventually occurs (Marmor 1988, McAuley et al. 2001, Engh 2002, Newman et al. 2009).
The negative influence of cancer therapy is a major rationale to investigate the effect of resistance exercise during adjuvant radiotherapy, as training in parallel to adjuvant treatment might prevent or mitigate treatment side effects such as fatigue.
A major rationale for sequencing large numbers of cancer genomes is to identify commonly mutated genes to inform diagnoses and treatments [ 1].
This seemed to have been a major rationale for St . Lukes Health Systems acquisition of Seltzer Medical Group, Idaho's largest independent, multi-specialty pHealth Systemsice group, which led to acquisitionst actiof.
One bovine hemoglobin-based solution under development relies on the naturally low affinity of bovine hemoglobin for oxygen as a major rationale for its use.
A major rationale for that policy is an effort to increase the diversity of programming.
Both sides cited economies of scale – significantly, their combined media-buying power – as a major rationale for the deal.
Gen. Dan Lungren and other supporters of the ballot initiative were highly critical of Pfaelzer's decision to invoke last year's federal welfare overhaul as a major rationale for throwing out Proposition 187.
A failure of the patient to respond adequately, and for the drug to show minimal impact on psychiatric symptoms, represents a major rationale for antipsychotic drug switching.
