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The phrase "a major rationale for" is correct and usable in written English.
It can be used when explaining the primary reason or justification for a particular action, decision, or belief.
Example: "The study highlights a major rationale for implementing renewable energy sources in urban planning."
Alternatives: "a key reason for" or "a significant justification for".
Exact(18)
Both sides cited economies of scale – significantly, their combined media-buying power – as a major rationale for the deal.
A major rationale for the proposed merger with Compaq, announced in September, was management's contention that the combined enterprise could trim costs by $2.5 billion, mainly by eliminating overlapping operations.
This seemed to have been a major rationale for St . Lukes Health Systems acquisition of Seltzer Medical Group, Idaho's largest independent, multi-specialty pHealth Systemsice group, which led to acquisitionst actiof.
And Obama has made it clear that a major rationale for the TPP is not promoting shared prosperity – the idealistic motivation that lay behind the birth of the Doha round – but creating a political and economic counterweight to the might of China.
But in April, when Mr. Obama released the Bush administration's legal opinions, which included extensive descriptions of the C.I.A.'s interrogation methods, the agency lost a major rationale for withholding the other documents, and it agreed to review them again for possible release.
A major rationale for the acquisitions had been and remains with the Allergan merger the benefits that would accrue to R&D.
Similar(42)
The other major rationale for a soul-based theory of life's meaning is that a soul is necessary for perfect justice, which, in turn, is necessary for a meaningful life.
After two recent conflicts – in Iraq and Afghanistan – in which, many allege, a secure energy supply was the major rationale for US involvement, the controversial practice known as hydraulic fracturing, or fracking, now offers the prospect of North American energy independence.
The major rationale for the follow-up of a hemorrhagic cyst is to assess resolution of the blood products.
The major rationale for such expansive treatment of O'Neill's formative years is that for O'Neill they truly were formative.
One major rationale for the application of heavy ion beams in tumor therapy is their increased relative biological effectiveness (RBE) in the Bragg peak region.
More suggestions(16)
a major success for
a major thing for
a major setback for
a major change for
a major cause for
a major embarrassment for
a convincing rationale for
a clear rationale for
a logical rationale for
a major blow for
a sound rationale for
a major pivot for
a major moment for
a classic rationale for
a new rationale for
a major shock for
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com