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The phrase "a major question when" is correct and usable in written English.
It can be used to introduce a significant inquiry or consideration that arises in a specific context or situation.
Example: "A major question when evaluating the effectiveness of the new policy is whether it truly benefits the community."
Alternatives: "a key issue when" or "an important question when".
Exact(2)
She said the exhibition would address what she considered a major question when looking at Moore: "Despite the fact that his work has become so ubiquitous, why have some scholars and critics come to dismiss this major figure?" In the 1960's art critics and scholars began to criticize Moore's work at the same time he was receiving more and more commissions for public projects.
While Ayala describes mutations and their effect on evolution, he doesn't go into how the mutations occur, which is a major question when explaining evolution.
Similar(58)
But they are relevant to our first major question – when did siboglinids evolve?
Current content caching systems have exploited the content popularity with temporal locality and users' interests to solving the major questions: when and what to cache?
The process of choosing these aspects is one of the major questions when applying user profiling.
There continues to be a major question as to when HA first appeared in vertebrate evolution.
A major question in retrotransposon biology is: when does most retrotransposition occur?
The insurer itself raised a major question about its value on Tuesday, when it acknowledged in a regulatory filing that it had not been forthcoming with investors about the adequacy of its reserves.
The balanced presentation afforded by convening a Citizens Juryy when considering a major question such as the introduction of a breast screening programme is advocated.
There are also spotlights situated at the bottom of the set area that zoom down on the contestant when they answer a major question; to increase the visibility of the light beams emitted by such spotlights, oil is vaporized, creating a haze effect.
Despite the numerous methods for CTC detection a major question that arises is whether these assays give the same information when analyzing the same clinical samples.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com