The phrase "a major question arising" is correct and usable in written English.
It can be used when introducing a significant issue or inquiry that has come up in a discussion or analysis.
Example: "In the context of climate change, a major question arising is how to effectively reduce carbon emissions globally."
Alternatives: "a significant question emerging" or "a key issue arising".
A major question arising from the analysis here is, therefore, which data could help to achieve an adequate integration of transport logistics hubs into transport demand modelling?
A major question arising from work with DAC inhibitors in CLL and related B-cell lymphoid malignancies is whether there is sufficient justification to pursue this class of drugs clinically.
A major question arising from our finding concerns the functional significance of apoptosis-like cell death in T. gondii.
A major question arising in genome-wide studies of transcription factor binding is that of the association between binding events and regulated genes.
A major question arising from this study is whether our current observation is relevant to other animal models or human SCI.
A major question arising from this study is whether MYCN activity is responsible for the focal growth of metastatic lesions, and whether and how it relates to the fewer affected body segments.
Considering the situation, a major question arises whether the companies are technologically capable of bringing supply chain resilience?
A major question arises from the nature of the proteins identified on the mechanisms of protein secretion.
6 Therefore, a major question arises as to which genes and which polymorphisms should be selected for further investigation of their possible associations with cancer.
The major question arising from these studies concerns the identity of rehydrins and what possible functions and roles they may play in regards to the response to desiccation and rehydration and to desiccation tolerance per se.
