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"a major problem with" is a correct and usable phrase in written English.
It is typically used to describe a significant issue or difficulty that someone or something is facing. It can be used in various contexts, such as discussing a situation, identifying a flaw, or pointing out a challenge. Example: "There is a major problem with the current transportation system. Many commuters are facing long delays and overcrowded buses on a daily basis."
Exact(60)
"We have a major problem with air quality.
A major problem with this approach is drug purity.
Unemployment is a major problem with our youths.
Public security remains a major problem, with nearly 50,000 homicides per year.
Dahlia Lithwick, perhaps without realizing it, exposed a major problem with liberalism.
"Guys had a major problem with him saying we don't have courage and heart," Martin said.
For now, however, this remains a major problem with no short-term fix.
A major problem with the I.O.C.'s effort to create a new policy is its opaqueness.
However, road congestion remained a major problem, with even the M25 seriously overloaded with traffic.
At the time there was a major problem with counting red blood cells.
But prosecutors uncovered a major problem with the war story: It never happened.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com