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The phrase "a major problem to" is not correct in standard written English.
It is typically used in contexts where one is discussing the impact or effect of a problem on something or someone, but it requires a preposition to complete the thought.
Example: "The lack of funding is a major problem to the success of the project."
Alternatives: "a significant issue for" or "a serious concern for".
Exact(37)
Insufficient gynecological examination skills were reported as a major problem to reproductive health service provision by a majority of informants, especially by those completing the vocational training program of general practice.
It also became increasingly clear that Mr. Prince, for the fifth time since taking the reins as chief executive, would have to disclose a major problem to his board.
The burkini bans – which are now seen as illegal – pose a major problem to the French state, which is responsible for making sure the rule of law is respected.
Hence, insider threat is inherently a major problem to address.
Drug resistance in coccidial populations has been a major problem to the prophylactic chemotherapy.
A major problem to solve is the quick growth of energy consumption in the Information and Communications Technologies (ICT) infrastructure.
Similar(22)
For an editor another major problem to resolve is how to move data.
Advance sensor data may warrant a proactive service event to prevent a major problem or to prioritize safety recall efforts.
28 29 Apnoeas are also known to be a major problem due to their potentially disastrous consequences in anaesthesia recovery rooms.
And it has turned into a major problem, according to technology companies and computer security experts.
A major problem, according to patent specialists, is that the patent office grants patents too easily in the first place.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com