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Isolation is a major problem, says Cooper.
The fate of expert advice offered to government has become a major problem, says Fiona Fox, head of the Science Media Centre.
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"This is a major problem," said Ding Shuang, a Citigroup analyst based in Hong Kong.
"This was a major problem," said Sanggaran, who worked at Christmas Island detention centre in 2013.
"These parties are a major problem," said James Duderstadt, president of the University of Michigan from 1988 to 1996.
A major problem, said Feng Yuan (not related to Angel Feng), is that it does not define gender discrimination.
"Fraud in immigration asylum is a huge issue and a major problem," said Denise N. Slavin, an immigration judge in Miami who is vice president of the National Association of Immigration Judges.
"That, I think, is a major problem," said Michael Fitzgerald, chairman of the College Savings Plans Network, a clearinghouse for information about 529 college savings plans.
"The quality of the infrastructure is a major problem," said Mesky Brhane, a senior urban specialist with the World Bank, who helped produce last year's report.
"When there's an economic problem in the region, Argentines stop coming and that causes a major problem," said Mónica Lozano, the hot springs specialist for the Uruguayan Ministry of Tourism.
"It won't be long before this goes from being a concern to being a major problem," said Brad Bourland, chief economist for the Saudi American Bank.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com