The phrase "a major problem lies" is correct and usable in written English.
It can be used when discussing a significant issue or challenge that exists in a particular context or situation.
Example: "In our analysis of the project, we found that a major problem lies in the lack of communication among team members."
Alternatives: "a significant issue exists" or "a critical challenge is present".
Well, those steeped in the system know that a major problem lies is in the level of performance of private companies which have won the contracts to manage basic court services under outsourcing arrangements.
A major problem lies in the varying number of miRNAs necessary to distinguish and classify specific cancer entities.
It is generally acknowledged that, among the several factors that hamper our current ability to attain efficient lignocellulosic biomass conversion yields at low enzyme loadings, a major problem lies in our incomplete understanding of the cooperative action of the different enzymes acting on pretreated lignocellulosic substrates.
A major problem lies in the "infinitely happy life" part.
These two types of knowledge pose different problems as to their representation: with regard to the explicit knowledge, the major problem lies in finding a vocabulary and a syntax shared by the community that faces a particular problem (and therefore produces a kind of knowledge that is oriented towards the action and is also determined by the action itself).
The major problem lies in the fact that we are stalled in this persistent paradigm of discovering new antibiotics.
This strongly suggests that the hybrid part of the engine is where the major problem lies, for it is with punch out of corners that the electrical energy plays the biggest part in performance.
For any attempt to assay the impact of aging per se on cognition in humans, the major problem lies in the selection criteria for subjects to be included in the study.
The major problem lies in the difficulty of differentiating the effect(s) of carbonylation from that of other protein modifications that occur simultaneously under oxidativing stress conditions (e.g. oxidation of cysteine thiols and nitration of tyrosine residues).
For molecular dating of prokaryotes, I have the feeling that the major problem lies in the use of global clocks, the absence of clear calibration points and the use of calibration points very far in time, such as the plant/animal split to date the divergence of a specific bacterial lineage, which has produced obvious overestimations in the literature (see papers by Hedges and colleagues).
But therein lies a major problem for objective baseball analysts: team chemistry, as perhaps baseball's most beloved intangible, defies all measurement.
