Sentence examples for a major problem however from inspiring English sources

A major problem, however, was that many contenders never considered the actual conditions of the contest, and so not one proposal aroused the board's interest for over 15 years!

A major problem however exists in this regard.

A major problem, however, has been finding the best strategies to implement these guidelines in a busy hospital environment.

Being overweight in adolescence is a major problem; however, limited evidence is available regarding effective and appealing intervention programs for overweight adolescents.

A major problem, however, with undertaking research in patients currently ill with AN, is the confounding effect of starvation, and thus low body mass index (BMI), on potential aetiological factors, such as altered emotional expression.

Selective reporting was not considered to be a major problem, however, because HFOV in adult patients was a relatively new treatment without strong prior beliefs or expectations on the side of the investigators.

One major problem, however, has been that when an electric voltage is applied across the film, DNA tends to move through the nanopore too quickly to read off all the bases in sequence.

The major problem, however, is that the sequence of an ncRNA evolves much faster than its structure, which implies that in most of the cases, no homology on the sequence level is detectable.

There is one major problem however: The biggest telecommunications players come from an entirely different mindset than the high-growth, go-go, data networking firms.

The major problem, however, is the querying procedure, since it requires detailed semantic knowledge about the content of specific database tables [ 13].

However, a major problem is still the computational effort caused by the combinatorical explosion of the number of possible routes or flux modes in a metabolic network at genome scale (Planes and Beasley, 2008).