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The phrase "a major problem for the" is correct and usable in written English.
It can be used when discussing significant issues or challenges faced by a particular group, organization, or situation.
Example: "The lack of funding has become a major problem for the local community center, affecting its ability to provide essential services."
Alternatives: "a significant issue for the" or "a critical challenge for the".
Exact(60)
The migrants pose a major problem for the Chinese.
Landing restrictions have been a major problem for the industry.
This is a major problem for the Phillies.
This presents a major problem for the environmental movement.
This is a major problem for the pharmaceutical industry.
Pigeons can be a major problem for the city dweller.
Serviceability is not a major problem for the hybrid tower.
His size could pose a major problem for the Hoyas' opponents.
Getting enough people to enlist could become a major problem for the next president.
A major problem for the organization was leadership and staffing, according to the report.
A major problem for the US is that too few of us – only 1% – study abroad.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com