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Physically-based erosion models are usually used for such purpose, but a major problem concerning their use is the difficulty to directly measure parameters in the field.
However, a major problem concerning their use is the difficulty of measuring their parameters in the field (Farias & Santos 2014; Vanmaercke et al. 2010).
A major problem concerning the addition of more drugs in a chemotherapy combination is designing a proper schedule assuring the balance between dose intensity of each drug, efficacy of the combination, and tolerability lessening the burden of drug toxicity.
Shazly also solved a major problem concerning anti-tank weaponry.
This is a major problem concerning the interpretation of the results and the message delivered.
A major problem concerning the study of these patients is the identification of robust prognostic parameters.
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A major problem concerned recovery from the loss of its oil wealth.
A major problem concerns underestimation, both on the clinical and microbiological level, of the cases of microbial pathogens introduced by internationally adopted children.
Nevertheless, one major problem concerning the effectiveness of current cervical screening programmes remains non-attendance.
The major problem concerning TB diagnosis for pregnant women is the delay in diagnosis, with a median delay time, defined as the duration from symptom onset to confirmation of diagnosis, ranging from 7 days to 6 months.
One major problem concerning Na channel blockers in the past is the fact that they can cause ventricular proarrhythmia as it was demonstrated in the Cardiac Arrhythmia Suppression Trial (CAST) trial [ 58].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com