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The phrase "a major problem at" is correct and usable in written English.
It can be used to indicate a significant issue occurring in a specific location or organization.
Example: "There is a major problem at the factory that needs immediate attention."
Alternatives: "a significant issue in" or "a critical concern at".
Exact(33)
All income groups chose the economy as their top issue, by far, and also cited the foreclosure crisis as a major problem, at the same rates (a slim majority of every group).
Organised tent theft continues to be a major problem at all festivals.
THE SCHOOLS Overcrowding is a major problem at Public School 8 in Bedford Park.
Nevertheless, 60percentt said corruption remained a major problem at the provincial level.
"She didn't come across as a major problem at all," he said.
He also said that a shortage of truck parking was a major problem at all the rest areas.
Similar(27)
For the home side, who sit in 13 six points above Palace in 18, the absence of influential defender Ron Vlaar is proving a major problem as they have conceded at least two goals in each of their last four matches, and defeat at the Britannia Stadium at the weekend means the midlands club have now only won two of their last 10 matches.
No system of free healthcare for the mass of the population was developed, illiteracy remained a major problem and at the end of the 1970s, despite the oil boom, the country's international debt was a major burden.
Is this really a major problem, or at least annoyance?
It's a major problem for at least one billion people.
The difficulties of CFS are similar to those of autism, precise diagnosis being a major problem; and at the time of writing, the question of murine retrovirus infection in CFS remains open.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com