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The phrase "a major problem associated" is correct and usable in written English.
It can be used when discussing significant issues that are linked to a particular subject or situation.
Example: "A major problem associated with climate change is the increase in extreme weather events."
Alternatives: "a significant issue related" or "a critical concern linked".
Exact(32)
The results of the majority of previous studies highlighted a major problem associated with the deficiency of the off-the-shelf, unidirectional open-web pultruded profiles.
A major problem associated with the burning of bituminous coal is air pollution.
Melanosis is a major problem associated with the quality loss of Pacific white shrimp.
A major problem associated with pattern recognition is the curse of dimensionality.
A major problem associated with the intensification of agriculture is the emergence of fungicide resistance.
However, coking is a major problem associated with reforming of heavy hydrocarbon fuels such as gasoline over different catalysts.
Similar(28)
Voltammetry at the liquid/liquid (water/1,2-dichloroethane) interface provides a simple method for overcoming the major problem associated with dopamine detection by voltammetry at solid electrodes: the co-existence of ascorbate at higher concentrations.
But the major problem associated with Pongamia biodiesel is its poor oxidation stability.
Thrombus formation is the major problem associated with biomaterials for blood contact medical devices.
The major problem associated with CP systems, stray current corrosion, is also discussed.
The major problem associated with the industrial production of PHB is its high production cost.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com