The phrase "a major problem as" is correct and usable in written English.
It can be used when introducing a significant issue that is related to or causes another situation or problem.
Example: "The lack of funding is a major problem as it hinders the progress of the project."
Alternatives: "a significant issue since" or "a critical concern because".
Trying to find candles was a major problem, as was the malnourishment of all of our actors.
Domestic violence was not really defined as a major problem as long as the kids weren't physically hurt.
I entered "Sophie's Choice" on my Intake äppärät, a major problem as far as Joshie was concerned.
The UN/African Union peacekeepers will take time to deploy, and could face serious supply constraints, with water likely to be a major problem, as well as limited co-operation from both the government and some rebel factions.
Deforestation has become a major problem, as much of the country's timber has been harvested for fuel because of shortages brought on by 20 years of warfare and for illegal export.
Conflicting and response-demanding input into the hemispheres is therefore not a major problem as long as stimuli are foveated.
Access to safe drinking water is a major problem, as is open defecation, which has the potential to trigger an epidemic.
Allelic dropout cannot be avoided easily but it does not represent a major problem as long as alleles/loci that might be affected by this phenomenon are identified and removed from the downstream analysis whenever appropriate.
This is a major problem, as during a long interval of several months to years, behavioural, emotional, and social changes unrelated to therapy may take place in chronic patients.
Splurging once in a while is not generally a major problem, as long as you get back to your diet the next day.
However, in the case of indolent lymphoma and MM patients who visit their physicians more often, this may not have been a major problem as the majority of those patients (95 %) was still under active follow-up.
