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The phrase "a major problem affecting" is correct and usable in written English.
You can use it when discussing significant issues that have an impact on a particular subject or area.
Example: "Climate change is a major problem affecting global agriculture and food security."
Alternatives: "a significant issue impacting" or "a critical challenge influencing".
Exact(20)
But for 2% of the population gambling was a major problem, affecting their families, he said.
Mental retardation is a major problem, affecting about 0.5 percent of young children.
Geographical segregation is a major problem affecting the income opportunities of slum dwellers.
Thrombus formation, due to thrombin generation, is a major problem affecting blood-contacting medical devices.
Primary failure of the arteriovenous fistula (AVF) is a major problem affecting native hemodialysis access use.
Under this method of extraction, strata control is a major problem affecting safety and productivity of the mine.
Similar(40)
A potential major problem affecting the methods described here is the challenge of integrating independent microarray studies.
Resistance to platinum is considered the major problem affecting prognosis.
Our focus group discussion revealed a major problem that affects HSB.
A major problem that affected children this summer was the terrible floods that ravaged parts of Romania's northeastern counties.
Substandard pharmaceuticals have continued to be a major problem that affects many countries all over the world, especially in Africa and southeast Asia.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com