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The phrase "a major population of" is correct and usable in written English.
It can be used when discussing a significant number of individuals within a specific group or demographic.
Example: "A major population of the city consists of young professionals who have recently moved in for job opportunities."
Alternatives: "a large segment of" or "a significant portion of".
Exact(28)
MDA-MB-231, DT-22 and DT-25 (Fig. 1 and Supporting Information Fig S1) were representative of the majority of TNBC cultures assayed with over 90%CD44++ cells, comprising a major population of CD44+CD24neg cells (>80%) and a minor CD44+ population with low level surface CD24 positivity or CD44+CD24low+ (<20%) cells (see Fig 1A).
A new study predicts for the first time that a major population of Atlantic cod, near Newfoundland, Canada, will essentially go extinct within 20 years, despite best attempts to manage it.
Radial glial (RG) cells constitute a major population of neural progenitor cells and are referred to vRG cells (ventricular radial glial cells); these cells occupy the proliferative ventricular zone (VZ) (Noctor et al., 2002; Hartfuss et al., 2001; Anthony et al., 2004).
A major population of this set of in vivo particles isolated under high salt condition might still represent snapshots of 30S assembly intermediates trapped in early stages of the 3′ domain assembly, characterized by extremely low levels of secondary and tertiary proteins in the 3′ domain.
Because the Kurdish people represent 15 to 18 million people in Turkey; they are the largest population without a country in the world and a major population of the Near East that has become a minority with the advent of the nation-state.
There's a major population of American Muslims committed to working hard and driving results in pursuit of a meaningful career that also makes their parents proud.
Similar(32)
This observation is likely the consequence of a major population bottleneck out of Africa.
These bitufted cells are probably equivalent to the low-threshold spiking cells which have been characterized as a second major population of inhibitory interneurons (supposedly somatostatin-containing) with many connectional properties different from basket cells (Beierlein et al. 2003).
While there are ups and downs, the annual Breeding Bird Survey shows no evidence of a major population change across the state from 1970 to 2000.
In Washington, the Quinault Indian Nation is also planning to relocate a major population center in the face of sea level rise, warmer temperatures and increasingly destructive storms.
This was not in the middle of a major population center.
More suggestions(16)
a tremendous population of
a substantial population of
a large population of
a broad population of
a considerable population of
a primary population of
a major demographic of
a large scale population of
a major constituents of
a major driver of
a major component of
a major point of
a major source of
a major cluster of
a major tragedy of
a major symptom of
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com