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With the γ-OH-PdG-adducted templates, the extent of the blockage to DNA synthesis was more severe, with a major pause site detected one nucleotide prior to the lesion and another pause site opposite the lesion.
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But when the infamous Kandahar run isn't closed for a major race, experts can pause for incredible views before charging the black trail nearly 3,000 vertical feet to the valley.
The pause-free velocities and apparent pause densities at various NTP concentrations are summarized in Table 1.> -wrap-foot> Backtrackisg is a major mechanism for transcriptional pauses.
"Even after the earnings, I don't think we will see a major correction but rather a pause or a breather since there isn't a major fundamental issue".
Certainly, but for now it appears the positive news flow from this group during the past few weeks, combined with the possibility of reinstating the uptick rule, has given the shorts reason to pause, creating a major tailwind.
Perhaps, like a biblical generation that represents a pregnant pause before a major transformation, we may be ready to act for a transformative rebirth in our time.
In biblical tradition, 40 is a ripe number, suggesting a pregnant pause before a major transformation: Moses and the Israelites wandering 40 years in the desert, Jesus' 40 days of temptation.
Other powerhouse women I've known and worked with have taken a pause in a major deal negotiation, or even put a deposition on hold, to answer a phone call from a child in need -- and have done so despite a few questionable looks from colleagues.
Trading in Monte dei Paschi Siena, Italy's oldest bank, which has been hit by a major scandal, has just been paused because its shares jumped so strongly.
After the project had to be paused for a major "reset" to prevent it going entirely off the rails, Devereux insisted that he was "extremely confident that we know what's going on now".
Single molecule analysis of DNA replication revealed that replication can initiate at other sites in EBV, and that OriP is a major site of replication fork pausing and termination [57].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com