The phrase "a major pathogenic factor" is correct and usable in written English.
It can be used in contexts related to health, disease, or medical research to describe a significant cause of disease or illness.
Example: "In the study of infectious diseases, understanding a major pathogenic factor is crucial for developing effective treatments."
Alternatives: "a significant disease-causing agent" or "a key pathogenic contributor."
The second section targets MCL-1, an antiapoptotic BCL-2 family protein that has emerged as a major pathogenic factor in human cancer.
Overload of the wrist extensors, which is considered to be a major pathogenic factor in lateral epicondylitis, can be reduced by braces.
Undesired activation of the complement system, a part of the immune system, is a major pathogenic factor contributing to various diseases, such as ischemia-reperfusion injury, sepsis, asthma, allergic reactions, rheumatoid arthritis, Alzheimer's disease, myasthenia, multiple sclerosis and others.
Microvascular disease is a major pathogenic factor for chronic kidney disease (CKD) in persons with diabetes, but the role of microvascular disease in the development of CKD in the general population is unclear.
It is known that free radicals are a major pathogenic factor in the development of ischemic damage in the muscle tissue [8].
At the same time, literature data indicate that ROS (for example, superoxide anion and hydroxyl radical) are a major pathogenic factor in ischemia-reperfusion tissue damage.
It has been proposed that both the innate and acquired immune systems may play a role in the progression of atherosclerosis, the major pathogenic factor responsible for most deaths in ESRD patients [ 21].
The major pathogenic factor of DM is hyperglycemia, which is a significant contributor to the accumulation of AGEs [13, 63].
Although the upregulation in stress response may have a role in disease progression, it is unlikely that this is the major pathogenic factor responsible for the development of locomotor deficits in tgMT mice.
Aims: The present study was designed to evaluate the oxidative stress as the major pathogenic factor of reflux esophagitis and the importance of antioxidant in treatment of reflux esophagitis.
The present study was designed either to evaluate the oxidative stress as the major pathogenic factor of reflux esophagitis or to find out the usefulness of antioxidant in the treatment of reflux esophagitis and the prevention of development of Barrett's esophagus.
