Sentence examples for a major pathogenic component from inspiring English sources

This gene encodes a transmembrane protein localized to the ER, suggesting that ER dysfunction is a major pathogenic component of Wolfram syndrome.

It is known that free radicals are a major pathogenic factor in the development of ischemic damage in the muscle tissue [8].

At the same time, literature data indicate that ROS (for example, superoxide anion and hydroxyl radical) are a major pathogenic factor in ischemia-reperfusion tissue damage.

These data confirm that TNF, apparently, is not a major pathogenic factor in pSS.

Moreover, although MOG accounts for only about 0.1% of total CNS myelin protein, MOG−/− mice showed a delayed onset of EAE when immunized with whole myelin and the clinical signs were significantly milder compared with WT mice, suggesting that anti-MOG response is the major pathogenic component of the autoimmune response directed against myelin.

ITSN-1s is one of the recently identified substrates for the cytotoxic protease granzyme B (GrB), [ 15], raising the possibility that during inflammatory processes, major pathogenic components of pulmonary vascular remodeling, [ 16], ITSN-1s can be cleaved and thus, expression of full-length protein reduced.

Oxidative stress is a major pathogenic mechanism of lead neurotoxicity.

Cardiomyocyte loss is a major pathogenic mechanism leading to heart failure.

Immunological dysregulation is now recognised as a major pathogenic event in sepsis.

We suggest that Nlrp3-mediated IL-1β activation in sepsis is a major pathogenic mechanism in inflammatory muscle atrophy.

Continuous endotracheal Pcuff-control is a way to minimize micro-aspiration of subglottic secretions, which is considered to be a major pathogenic mechanism of VARI.