In epidemiology, substantial (local) epidemic spread is called a major outbreak to distinguish it from minor outbreaks implying self-limiting (local) spread.
The virus was believed to have spread from a major outbreak in Hong Kong (22 ).
In 1969, variant I-A/B virus was transported from a major outbreak in northern South America to the borders of El Salvador, Guatemala, and Honduras.
The clade Ic viruses caused the largest major DENV-1 outbreak in Malaysia in 2004 and the viruses shared high sequence similarity to isolates recovered from a major outbreak in Singapore in 2005 [ 35].
Recently, numerous cases of CHIKV infection have been reported from a major outbreak of febrile illness around the Indian Ocean, which included Comoros, Mauritius, Réunion Island (2, 3 ), and southern India (4 ).
In 2004, a major outbreak of hepatitis A among tourists returning from Egypt involved 351 case-patients from 9 European countries who were infected with a single strain (genotype 1b).
During 8 months from July 2012 to February 2013, a major outbreak of canine distemper involving 64 mink farms occurred on the Danish peninsula of Jutland.
Although Iraq suffered a major outbreak of polio in 1999, increased assistance from UNICEF and WHO has led to zero cases since January 2000.
For example, in August 2000 an imported poliovirus from Angola caused a major outbreak on the small West African island nation of Cape Verde, which had been polio-free for years.
Nipah virus (NV) caused a major outbreak in swine and humans in Malaysia from September 1998 to April 1999 that led to 265 human cases with 105 deaths and the culling of >1 million swine (1 ).
