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Even stairs are a major obstacle.
A major obstacle is Mosul.
It's also a major obstacle to drug delivery.
But there was a major obstacle: Syria's support for Hezbollah.
The Drava River was certainly a major obstacle.
Laurent Kabila was a major obstacle to peace in Congo.
For Fidyka, though, a major obstacle remained: the cost.
A major obstacle is the instability of global culture.
Articular cartilage repair remains a major obstacle in tissue engineering.
Drug resistance is a major obstacle in modern medicine.
The IMF's stance is a major obstacle.
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CEO of Professional Science Editing for Scientists @ prosciediting.com