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The phrase "a major negative" is correct and usable in written English.
It can be used to describe a significant disadvantage or drawback in a situation or context.
Example: "The high cost of living in the city is a major negative for many potential residents."
Alternatives: "a significant drawback" or "a considerable disadvantage."
Exact(60)
"If the country keeps receding, or even disappeared, there is hardly anything that would have a major negative impact abroad.
"At this juncture, we are in a crisis that could have a major negative impact on this country".
So far, the war, by itself, does not appear to have had a major negative impact on the economy.
But it caused a sizable increase in blood pressure, a major negative effect for patients with heart disease.
The Brexit vote represents a major negative shock not only to the UK but also to global output.
Conservationists said the report was shocking, showing that modern agricultural techniques had had a major, negative impact on wildlife.
You're going to have a major negative impact on the economy.' " The executives left frustrated.
What must be challenged is that instruments intended to enhance security will clearly have a major negative impact on those who are most at risk.
Every other relationship starts with a major negative to negotiations, requiring many turns of diplomacy and bribery to even get on an even footing.
However, radiation damage remains a major negative consequence of radiotherapy.
Obesity is a major negative determinant of breast cancer outcome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com